Other benefits of lutein for eye health include: When it comes to eye health, every person is different in terms of how much lutein is most beneficial. A., de Vries, A. J., Goldbohm, R. A., Tijburg, L. B., Kardinaal, A. F., and van Poppel, G. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. View abstract. Machida N, Kosehira M, Kitaichi N. Clinical effects of dietary supplementation of lutein with high bio-accessibility on macular pigment optical density and contrast sensitivity: A randomized double-blind placebo-controlled parallel-group comparison trial. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Dagnelie G, Zorge IS, McDonald TM. Lutein supplements have been used safely by adults in doses up to 15 to 20 milligrams daily for as long as two years without any serious side effects. B., Xu, X. R., Zou, Z. Y., and Lin, X. M. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: The GUSTO Study. Edwards CG, Walk AM, Thompson SV, et al. Bartlett, H. E. and Eperjesi, F. Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial. JAMA Ophthalmol 2022. There arent any known special precautions for women who are pregnant or breastfeeding, but its always a good idea to speak with your doctor when pregnant before beginning new supplemental treatments. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Br J Nutr 2001;85(2):227-238. Bonds DE, Harrington M, Worrall BB, et al. Olestra affects serum concentrations of alpha-tocopherol and carotenoids but not vitamin D or vitamin K status in free-living subjects. View abstract. View abstract. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Lutein and zeaxanthin status and risk of age-related macular degeneration. View abstract. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. Snodderly DM. Ophthalmology 2003;110(1):51-60. SanGiovanni, J. P. and Neuringer, M. The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field. Taylor, A., Jacques, P. F., Chylack, L. T., Jr., Hankinson, S. E., Khu, P. M., Rogers, G., Friend, J., Tung, W., Wolfe, J. K., Padhye, N., and Willett, W. C. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities. Thurnham, D. I., Northrop-Clewes, C. A., Paracha, P. I., and McLoone, U. J. Some evidence shows that people who obtain more lutein from their diets experience lower rates of breast, colon, cervical and lung cancers. Slattery ML, Benson J, Curtin K, et al. When we eat foods high in lutein or take it in supplement form, its believed to be pretty easily transported around the body, especially to the parts of the eyes called the macula and the lens. Am J Hypertens. Albanes D, Virtamo J, Taylor PR, et al. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Nicknamed the eye vitamin, lutein is a type of carotenoid antioxidant that is most well-known for protecting eye health. Ophthalmol Sci 2021;1(3):100039. J Am Coll Nutr 2019;38(2):179-184. 2003;57(9):1135-1140. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. As another example, one group of people who can usually afford to take more is those with cystic fibrosis. Am J Clin Nutr 2005;82:88-97. Ophthalmology 2012;119(11):2290-2297. 2003;16(8):665-672. Lutein and zeaxanthin intake during pregnancy and visual function in offspring at 11-12 years of age. View abstract. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. Invest Ophthalmol.Vis.Sci. Kang T, Liu Y, Chen X, et al. View abstract. View abstract. View abstract. Gruber M, Chappell R, Millen A, et al. Johnson EJ, Hammond BR, Yeum KJ, et al. Invest Ophthalmol.Vis.Sci. Landrum JT, Bone RA, Joa H, et al. Lyle BJ, Mares-Perlman JA, Klein BE, et al. Lutein /zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. Along with another vision-boosting carotenoid called zeaxanthin, it is abundant in anti-inflammatory,cancer-fighting foodsincluding kale, broccoli and many other green vegetables, eggs yolks, and citrus fruits all of which studies show help protect the eyes from oxidative stress. Roodenburg AJ, Leenen R, van het Hof KH, et al. Exp Eye Res. A., and Guymer, R. H. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. An ancillary study of the women's health initiative. Slattery ML, Potter JD, Coates A, et al. Some animal studies show evidence that lutein offers significant protection against light-induced skin damage, such as signs of aging and potentially skin cancer. Bernstein PS, Li B, Vachali PP, Gorusupudi A, Shyam R, Henriksen BS, Nolan JM. Djuric, Z., Uhley, V. E., Naegeli, L., Lababidi, S., Macha, S., and Heilbrun, L. K. Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. Carotenoid intake and esophageal cancer risk: a meta-analysis. Mares-Perlman JA, Brady WE, Klein BE, et al. VandenLangenberg GM, Mares-Perlman JA, Klein R, et al. 2009;41(9):1752-1760. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. Takeda A, Nyssen OP, Syed A, et al. View abstract. Mahmassani HA, Switkowski KM, Johnson EJ, et al. Front Nutr 2022;9:924997. Upritchard, J. E., Schuurman, C. R., Wiersma, A., Tijburg, L. B., Coolen, S. A., Rijken, P. J., and Wiseman, S. A. Dietary intake of antioxidants and risk of age-related macular degeneration. Researchers at Harvard University have found that supplementing with lutein daily can lower the risk for macular degeneration. Effect of long-chain ?-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 1998;7(6):537-544. Giving preterm infants lutein and zeaxanthin by mouth doesn't prevent retinopathy of prematurity. Am.J.Clin.Nutr. A case-control study. Glucosamine: 2 people, 18.18%. JAMA Ophthalmol 2015;133(12):1415-24. 1995;36(12):2531-2541. J Am Optom.Assoc 1999;70(1):24-36. View abstract. Pickup & Same Day Delivery available on most store items. Nutr.J. Arch.Ophthalmol. JAMA 2013;309(19):2005-2015. A., Liu, C., Tang, G., Krinsky, N. I., and Russell, R. M. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. WebLutein, zeaxanthin, lycopene, and astaxanthin belong to a group of nutrients called carotenoids. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli, Brussels sprouts, eggs, oranges, and papaya. Int J Food Sci Nutr 2016;67(7):744-53. 2014 May;174(5):763-71. View abstract. They are also found in many dark green vegetables; however the large amounts of Eur J Clin Nutr 2007;61:1167-73. Antioxidant status and neovascular age-related macular degeneration. View abstract. Molldrem, K. L., Li, J., Simon, P. W., and Tanumihardjo, S. A. Lutein and beta-carotene from lutein-containing yellow carrots are bioavailable in humans. Lutein is found in the retina, where it is thought to protect the eye from the 7-15-2001;391(2):160-164. 2011;94(5):1211-1218. Broekmans, W. M., Berendschot, T. T., Klopping-Ketelaars, I. View abstract. 2012;32(6):418-424. Bone, R. A., Landrum, J. T., Dixon, Z., Chen, Y., and Llerena, C. M. Lutein and zeaxanthin in the eyes, serum and diet of human subjects. View abstract. View abstract. Am.J Clin.Nutr 1996;64(4):594-602. Biomed Res 2011;32(6):387-393. Arch.Biochem.Biophys. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Lutein has no known severe, serious, moderate, or mild interactions with other drugs. This information does not contain all possible interactions or adverse effects. Photochem.Photobiol. Studies done by the University of Southern California suggest that low levels of lutein within the blood might contribute to the thickening of artery walls. 2015 Aug 25;314(8):791-801. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. Johnson, E. J. The human body cannot synthesize lutein or zeaxanthin on its own, which means we must obtain these important nutrients from our diets (or, in some cases, supplements). View abstract. Nutrition 2003;19(3):244-249. 2013;54(3):1781-1788. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Wright, A. J., Hughes, D. A., Bailey, A. L., and Southon, S. Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers. Bartlett, H. E. and Eperjesi, F. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Bone, R. A., Landrum, J. T., Mayne, S. T., Gomez, C. M., Tibor, S. E., and Twaroska, E. E. Macular pigment in donor eyes with and without AMD: a case-control study. Am J Clin Nutr 2004;79 1045-52. Aune, D., Chan, D. S., Vieira, A. R., Navarro Rosenblatt, D. A., Vieira, R., Greenwood, D. C., and Norat, T. Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. Gouado, I., Schweigert, F. J., Ejoh, R. A., Tchouanguep, M. F., and Camp, J. V. Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice). Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. View abstract. A. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). View abstract. Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study. View abstract. View abstract. Murray, I. J., Makridaki, M., van der Veen, R. L., Carden, D., Parry, N. R., and Berendschot, T. T. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. View abstract. Am J Respir Crit Care Med 2001;163:1246-55.. View abstract. Am.J.Clin.Nutr. 2012;96(5):1207S-1213S. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. Diabetes Care 2022;45(6):1453-1461. Nutrients. Nutrients 2017;9(11):1246. Zhao, X., Aldini, G., Johnson, E. J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N. I., Russell, R. M., and Yeum, K. J. View abstract. Int J Vitam.Nutr Res. View abstract. Eye Disease Case-Control Study Group. 2014 Jan;252(1):63-70. View abstract. J Sci Food Agric. 2002;56(7):615-621. J.Nutr. Cancer Epidemiol.Biomarkers Prev. View abstract. View abstract. Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V., Kealey, S., and Pierce, J. P. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. Ophthalmologica 2017;237(3):159-66. View abstract. The first 200 years. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. This carotenoid is obtained from both foods and supplements, which are generally considered safe. Oncotarget 2017;8(2):2391-9. It's related to beta-carotene and vitamin A. Lutein-rich foods include egg yolks, broccoli, spinach, kale, corn, orange pepper, kiwi fruit, grapes, orange juice, zucchini and squash. Skin Pharmacol.Physiol 2007;20(4):199-210. This includes a 2018 study in which researchers concluded: Dietary lutein supplementation may be a promising alternative and/or adjunct therapeutic candidate against breast cancer.. Since the plant Estimates show that more than 25 million people worldwide are affected by age-related macular degeneration or cataracts, especially people aged 55 and older living in industrialized Western nations. , zeaxanthin, lycopene, and Guymer, R. H. dietary antioxidants and primary prevention of.... Bernstein PS, Li B, Vachali PP, Gorusupudi A, C, and E, astaxanthin. Supplementing lutein for eczema lutein daily can lower the risk for macular degeneration br, Yeum KJ, et al people obtain! 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