Unable to load your collection due to an error, Unable to load your delegates due to an error. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. tramadol and doxepin both increase sedation. Minor (1)doxepin increases effects of insulin aspart by pharmacodynamic synergism. doxepin and histrelin both increase QTc interval. Minor/Significance Unknown. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of doxepin by decreasing metabolism. neostigmine increases and doxepin decreases cholinergic effects/transmission. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Either increases effects of the other by serotonin levels. Effect of interaction is not clear, use caution. Mechanism: unspecified interaction mechanism. Effect of interaction is not clear, use caution. Use Caution/Monitor. benperidol and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)doxepin and voclosporin both increase QTc interval. doxepin increases and dopamine decreases sedation. Minor/Significance Unknown. Use Caution/Monitor. This drug is available at a higher level co-pay. Avoid or Use Alternate Drug. All generic drug interactions for doxepin top (lists will include brand and generic names): 21 contraindicated drug interactions 63 serious drug interactions 464 significant drug interactions 161 minor drug interactions Patients and Caregivers Clinician Explanation Monitor Closely Potential for interaction bupropion hcl oral and doxepin top If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. doxepin increases effects of insulin regular human by pharmacodynamic synergism. amoxapine and doxepin both increase serotonin levels. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. Use Caution/Monitor. Cyclic antidepressants are designated as tricyclic or tetracyclic, depending on the number of rings in their chemical structure three (tri) or four (tetra). Symptoms may vary depending on how the drug works. Use Caution/Monitor. Contraindicated. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Contraindicated (1)tranylcypromine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Monitor Closely (1)buprenorphine buccal and doxepin both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin and rilpivirine both increase QTc interval. Monitor Closely (1)physostigmine increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Monitor Closely (1)succinylcholine increases and doxepin decreases cholinergic effects/transmission. doxepin and posaconazole both increase QTc interval. Use Caution/Monitor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Monitor Closely (2)doxepin increases and levalbuterol decreases sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Effect of interaction is not clear, use caution. Accessed Aug. 20, 2019. doxepin and pimozide both increase QTc interval. Minor/Significance Unknown. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor Closely (1)doxepin and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. and transmitted securely. cinnarizine and doxepin both increase sedation. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by sedation. and can have potentially adverse consequences. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Either increases effects of the other by pharmacodynamic synergism. Either increases toxicity of the other by serotonin levels. Mechanism: unspecified interaction mechanism. Accessed Aug. 19, 2019. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and daridorexant both increase sedation. Use Caution/Monitor. doxepin increases effects of glimepiride by pharmacodynamic synergism. Insomnia Treatment Update With a Focus on Orexin Receptor Antagonists. Minor/Significance Unknown. Profound sedation, respiratory depression, coma, and death may result if coadministered. dexmethylphenidate increases effects of doxepin by decreasing metabolism. USES: This medication is used to treat a certain sleep problem (insomnia). tapentadol and doxepin both increase sedation. Interactions between your drugs Major buPROPion doxepin Applies to: Wellbutrin (bupropion) and doxepin Talk to your doctor before using buPROPion together with doxepin. Contraindicated. Cyclic antidepressants block the reabsorption (reuptake) of the neurotransmitters serotonin (ser-o-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin), increasing the levels of these two neurotransmitters in the brain. doxepin increases and albuterol decreases sedation. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dopamine. Use Caution/Monitor. DrugGenius225 S. Mermac AveUnit 832TClayton, MO 63131. Accessed Aug. 19, 2019. Modify Therapy/Monitor Closely. Accessed Aug. 19, 2019. doxepin and levalbuterol both increase QTc interval. onabotulinumtoxinA and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.doxepin increases toxicity of oliceridine by Other (see comment). Monitor Closely (2)doxepin and methadone both increase QTc interval. Minimally clinically significant. Use Caution/Monitor. Monitor Closely (1)frovatriptan and doxepin both increase serotonin levels. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, methamphetamine. Tricyclic and tetracyclic antidepressants affect brain chemicals to ease depression symptoms. chloral hydrate and doxepin both increase sedation. fedratinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Monitor Closely (1)carisoprodol and doxepin both increase sedation. doxepin, sodium oxybate. Use Caution/Monitor. Contraindicated. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. metaxalone and doxepin both increase sedation. Minor/Significance Unknown. Bupropion is sold under different brand names. Use Caution/Monitor. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. doxepin, epinephrine. Tips Avoid or Use Alternate Drug. Contraindicated. Monitor Closely (2)doxepin increases effects of epinephrine racemic by unknown mechanism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin brand names and other generic formulations include: bupropion hcl oral brand names and other generic formulations include: Budeprion SR Oral, Budeprion XL Oral, Buproban Oral, Forfivo XL Oral, Wellbutrin Oral, Wellbutrin SR Oral, Wellbutrin XL Oral, Zyban Oral. Avoid or Use Alternate Drug. Minor/Significance Unknown. Mechanism: unspecified interaction mechanism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dexmethylphenidate. Contraindicated. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Minor/Significance Unknown. phenobarbital and doxepin both increase sedation. doxepin and topiramate both increase sedation. perphenazine and doxepin both increase sedation. remimazolam, doxepin. Monitor Closely (1)flavoxate and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and ceritinib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Additive anticholinergic effects. What are the signs and symptoms of hidradenitis suppurativa? clomipramine and doxepin both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)belladonna alkaloids and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. doxepin and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (2)belladonna and opium and doxepin both decrease cholinergic effects/transmission. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin and lofexidine both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and olanzapine both increase QTc interval. Other (see comment). doxepin, isoproterenol. Minor (1)estrogens conjugated synthetic, doxepin. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.Minor (1)primidone, doxepin. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. trifluoperazine and doxepin both increase sedation. Serious - Use Alternative (1)fosamprenavir increases levels of doxepin by decreasing metabolism. olanzapine and doxepin both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. doxepin and orphenadrine both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.Monitor Closely (1)doxepin and lefamulin both increase QTc interval. information and will only use or disclose that information as set forth in our notice of Monitor Closely (1)terbinafine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. ECG monitoring is recommended if coadministered. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Talk to your doctor before using buPROPion together with doxepin. Avoid or Use Alternate Drug. Symptoms of overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow breathing, seizures. Avoid or Use Alternate Drug. The recipient will receive more details and instructions to access this offer. Avoid or Use Alternate Drug. desipramine and doxepin both increase sedation. Monitor Closely (1)doxepin and atomoxetine both increase QTc interval. Use Caution/Monitor. diazepam and doxepin both increase sedation. Avoid or Use Alternate Drug. duloxetine and doxepin both increase serotonin levels. Use Caution/Monitor. Avoid combination within 14 days of MAOI use. Use Caution/Monitor. doxepin and romidepsin both increase QTc interval. Monitor Closely (1)doxepin and dihydroergotamine intranasal both increase serotonin levels. triazolam and doxepin both increase sedation. Monitor Closely (1)doxepin and saquinavir both increase QTc interval. Some tricyclic antidepressants are more likely to cause side effects that affect safety, such as: Other issues to discuss with your doctor before you take a cyclic antidepressant: Most antidepressants are generally safe, but the FDA requires that all antidepressants carry black box warnings, the strictest warnings for prescriptions. Monitor Closely (1)doxepin and alfuzosin both increase QTc interval. Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. Monitor Closely (1)amobarbital and doxepin both increase sedation. Other (see comment). Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Use Caution/Monitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. tipranavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Input your search keywords and press Enter. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Mechanism: unspecified interaction mechanism. Monitor Closely (1)henbane and doxepin both decrease cholinergic effects/transmission. Other (see comment). Modify Therapy/Monitor Closely. Monitor Closely (1)glycopyrronium tosylate topical, doxepin. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. triprolidine and doxepin both increase sedation. physostigmine increases and doxepin decreases cholinergic effects/transmission. Coadministration may increase risk of serotonin syndrome. Use Caution/Monitor.diphenhydramine and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. If you require treatment for more than 7 to 10 days, lab and/or medical tests should be done to find the cause of your sleep problem. Monitor Closely (1)chloral hydrate and doxepin both increase sedation. buprenorphine buccal and doxepin both increase sedation. Other (see comment). With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor.doxepin and nortriptyline both increase sedation. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin and ondansetron both increase QTc interval. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. homatropine and doxepin both decrease cholinergic effects/transmission. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Monitor Closely (1)nalbuphine and doxepin both increase sedation. Concomitant use could result in life-threatening serotonin syndrome. Use Caution/Monitor. Severe Interactions These medications are not usually taken together. Use Caution/Monitor.Minor (1)butalbital, doxepin. restrictions. Coadministration may increase risk for adverse effects of CYP3A4 substrates. doxepin and nabilone both increase sedation. A double-blind controlled study comparing the effects of bupropion to doxepin in outpatients with primary depression was conducted to evaluate efficacy and safety differences between the two drugs. Minor/Significance Unknown. Use Caution/Monitor. doxepin and desvenlafaxine both increase serotonin levels. Additive anticholinergic effects. Other (see comment). Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.risperidone and doxepin both increase sedation. sufentanil and doxepin both increase sedation. Monitor Closely (1)rizatriptan and doxepin both increase serotonin levels. There are 485 drugs known to interact with Wellbutrin XL (bupropion), along with 8 disease interactions, and 1 alcohol/food interaction. Monitor Closely (1)doxepin increases and phendimetrazine decreases sedation. Either increases effects of the other by serotonin levels. Natural remedies for depression: Are they effective? doxepin and mirtazapine both increase sedation. Coadministration may increase risk of serotonin syndrome. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and doxepin both increase QTc interval. Use Caution/Monitor.doxepin and apomorphine both increase QTc interval. Use Caution/Monitor. So avoiding it may be advised. Minor (1)maraviroc will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (2)doxepin and trazodone both decrease cholinergic effects/transmission. Migraine treatment: Can antidepressants help? Avoid or Use Alternate Drug. Exact mechanism for doxepin's sleep maintenance effect is unknown; however, doxepin's action is believed to result from antagonism of the histamine H1 receptor, Mechanism of action for depression is unknown; may increase CNS synaptic concentrations of serotonin and norepinephrine by inhibiting reuptake. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin, epinephrine. Avoid or Use Alternate Drug. doxepin increases and midodrine decreases sedation. doxepin, promethazine. estropipate, doxepin. Minor (1)hydroxyprogesterone caproate, doxepin. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, yohimbine. dichlorphenamide and doxepin both decrease serum potassium. Use Caution/Monitor. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: cimetidine.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Modify Therapy/Monitor Closely. Use Caution/Monitor. thyroid desiccated increases effects of doxepin by Other (see comment). Limit dosages and durations to the minimum required. Use Caution/Monitor.doxepin and propafenone both increase QTc interval. unspecified interaction mechanism. Monitor Closely (1)doxepin and lsd both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor.doxepin increases toxicity of bupropion by unspecified interaction mechanism. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Monitor Closely (1)temazepam and doxepin both increase sedation. Monitor Closely (1)metaxalone and doxepin both increase sedation. Minor (1)doxepin increases effects of acarbose by pharmacodynamic synergism. Avoid or Use Alternate Drug.paroxetine and doxepin both increase serotonin levels. palonosetron, doxepin. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. How to tell if a loved one is abusing opioids. Monitor Closely (1)doxepin increases and methamphetamine decreases sedation. Either increases levels of the other by decreasing metabolism. May cause increase or decrease in blood pressure. Available for Android and iOS devices. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.doxepin increases effects of lasmiditan by serotonin levels. Minor (1)doxepin increases effects of tolazamide by pharmacodynamic synergism. doxepin, perphenazine. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Monitor Closely (1)liothyronine increases effects of doxepin by Other (see comment). Modify Therapy/Monitor Closely. Monitor Closely (1)homatropine and doxepin both decrease cholinergic effects/transmission. doxepin and flecainide both increase QTc interval. Other (see comment). Other (see comment). Accord Healthcare Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd. Minor/Significance Unknown. Available for Android and iOS devices. Potential for additive anticholinergic effects. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, methylenedioxymethamphetamine. Monitor Closely (1)doxepin and meprobamate both increase sedation. Additive anticholinergic effects.doxepin, trifluoperazine. doxepin and eucalyptus both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, arformoterol. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, phenylephrine. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and paliperidone both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Additive anticholinergic effects. Concomitant use could result in life-threatening serotonin syndrome. doxepin, prochlorperazine. This drug is available at a higher level co-pay. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Minor (1)mestranol, doxepin. Other (see comment). estazolam and doxepin both increase sedation. Avoid or Use Alternate Drug. lurasidone increases effects of doxepin by Other (see comment). Use Caution/Monitor. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Either increases levels of the other by decreasing metabolism. Careers. May give qHS to decrease daytime sedation, To minimize potential for next day drowsiness, do not take within 3 hr of a meal (AUC increased by 41% and Cmax by 15% when taken with high fat meal), calcium/magnesium/potassium/sodium oxybates, elvitegravir/cobicistat/emtricitabine/tenofovir DF, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol, Neonates exposed to TCAs, including doxepin, late in third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding; such complications can arise immediately upon delivery, Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hyperreflexia, tremor, jitteriness, irritability and constant crying. dimenhydrinate and doxepin both increase sedation. Use Caution/Monitor.doxepin and trazodone both increase sedation. liothyronine increases effects of doxepin by Other (see comment). These findings are consistent with either direct toxic effects of TCAs or possibly a drug discontinuation syndrome, Monitor neonates who were exposed to drug in third trimester of pregnancy for poor neonatal adaptation syndrome, Based on results from animal fertility studies conducted in rats, doxepin may reduce fertility in females and males of reproductive potential, In animal reproduction studies, oral administration of doxepin to rats and rabbits during period of organogenesis caused adverse developmental effects at doses 65 and 23 times maximum recommended human dose (MRHD) of 6 mg/day based on AUC, respectively, Oral administration to pregnant rats during pregnancy and lactation resulted in decreased pup survival and a delay in pup growth at doses 60 times MRHD based on AUC. Hypothyroidism symptoms: Can hypothyroidism cause eye problems? You may be more likely to experience seizures with these medications if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Use Caution/Monitor.doxepin and trimipramine both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. doxepin increases and modafinil decreases sedation. Highly clinically significant. Accessed Sept.12, 2019. Minor/Significance Unknown. Sedatives are not technically considered antidepressants. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Other (see comment). Monitor Closely (1)buprenorphine and doxepin both increase sedation. Use Caution/Monitor. methocarbamol and doxepin both increase sedation. anticholinergic/sedative combos and doxepin both decrease cholinergic effects/transmission. doxepin, buprenorphine subdermal implant. Serious - Use Alternative (1)buprenorphine transdermal and doxepin both increase QTc interval. Use Caution/Monitor.doxepin and thiothixene both increase QTc interval. Monitor Closely (1)gabapentin enacarbil, doxepin. Increased antidepressant serum concentrations may occur. Minor/Significance Unknown. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Additive anticholinergic effects. Which antidepressant is best for you depends on a number of issues, such as your symptoms and any other health conditions you may have. Use Caution/Monitor. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Use Caution/Monitor. The effects may be increased because of slower removal of the medicine from the body. Modify Therapy/Monitor Closely. doxepin and melatonin both increase sedation. doxepin and selpercatinib both increase QTc interval. Most Use Caution/Monitor. pimozide and doxepin both increase sedation. Monitor Closely (1)doxepin and voriconazole both increase QTc interval. Separating Fact From Fiction. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Minor/Significance Unknown. The information provided here is for informational purposes only. Use Caution/Monitor. Effect of interaction is not clear, use caution. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. Taking doxepin with gabapentin (Neurontin) could therefore increase certain side effects of CNS depression, such as dizziness, confusion, and trouble concentrating. This content does not have an Arabic version. Either increases toxicity of the other by sedation. Monitor Closely (1)cevimeline increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. doxepin increases effects of chlorpropamide by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. Other (see comment). doxepin and 5-HTP both increase serotonin levels. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. Use Caution/Monitor. Monitor Closely (1)chlorpheniramine and doxepin both increase sedation. Mechanism: unspecified interaction mechanism. Additive anticholinergic effects.doxepin, prochlorperazine. Use Caution/Monitor. Use Caution/Monitor. This is a decision you and your doctor will make. Use Caution/Monitor. linezolid and doxepin both increase serotonin levels. other information we have about you. Or consider reducing the dosage of the other by mechanism: pharmacodynamic.. All material on this website is protected by copyright, copyright 1994-2023 by WebMD LLC and both.: how to use this information: this is a decision you and your doctor all. 1 alcohol/food interaction succinylcholine increases and levalbuterol both increase sedation, identify pills check. Inc. ; 2018. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd, methamphetamine succinylcholine increases and decreases! Be increased because of slower removal of the other by serotonin levels ) belladonna alkaloids and doxepin both QTc. Tricyclic antidepressant effects, including respiratory depression an error, unable to load your delegates due to an error unable! Fainting, slow/shallow breathing, seizures include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow,. 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