[CDATA[ Methyl groups are small molecules that are put on DNA, proteins, and substances in order for them to work properly. ", This is a loss of protein homeostasis due to misfolded proteinsold proteins [at the cellular level]. Dr David Sinclair has suggested that aging is a diseaseand that we may soon have the tools to put it into remissionand he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives. We would prefer lower doses spread over the day, like 500 mg twice daily, before lunch (500 mg) and before dinner (500 mg) not in the morning because this is when the body is already most insulin-sensitive anyhow. And we dont know how we each respond to drugs because none of us is an average human being. Examples of continuous glucose monitors are FreeStyle Libre or Levels (not sponsored). David Sinclair, one of the world's leading longevity experts and Professor in Harvard Genetics Department, join Nick and Lisa for an interview in this latest. The amount of old people who stick around is not going to be anywhere near as many as people imagine. Spermidine is a molecule first found in sperm, hence its name. Our view: combining TMG with NMN makes sense, but we prefer phosphatidylcholine (or a combination of TMG with phosphatidylcholine). Theyve discovered that the sooner they are turned on, the better it is. The career of David Sinclair follows a link between sirtuins, resveratrol, NAD-boosting anti-aging . Update: January 2023 An important new paper from Dr. David Sinclair and his team at Harvard concludes that loss of epigenetic information causes mammalian aging. Get in touch by phone (800) 513-2359 or email He is an inventor on 35 patents and has received more than 35 awards and honors. I don't want any teenagers to use this as a reason to not eat enoughbut most adults eat too much and they eat too often. Now Available: NOVOS Age, the biological age clock by Columbia & Duke University scientists. Of course, Dr. Sinclair does not only rely on supplements to live longer and healthier. He's the co-director of the Paul F. Glenn Center for the Biology of Aging and has been a member of our scientific advisory board here at InsideTracker since the early days of the company. In humans, we see that diabetics taking metformin actually live longer than healthy non-diabetics who obviously dont take metformin (R). Various studies show that coenzyme Q10 does not extend lifespan (R,R,R,R). Metformin inhibits mitochondrial function, so the mitochondria will repair and protect themselves better. Learn more about the differences between NMN and NR here. Sinclair discloses his personal routine in the final chapter of his book, which is as follows: Dr. Sinclair highlights the need of taking no shortcuts when it comes to diet and exercise planningthe greatest method to extend life expectancy is to consume a balanced diet of nutritious foods, taking care not to overload the body with fructose or simple sugars. They're also turned on particularly by high intensity exercise. We know that breaking a chromosome is the best way to accelerate aging. Professor Sinclair considers NMN to be superior to NR. David never shares brand names, but we know and trust 2 in particular: Elysium Basis: NR/pterostilbene Combo, NR is a smaller variant of NMN that has been shown to be better at entering cells . He has co-founded ten biotechnology companies in the areas of aging, vaccines, diabetes/cancer, biodefense, forensics, and bioinformatics. He stresses that while modern technology paved the way to curing plenty of diseases that were incurable before the 20th century, its still not enough. He was educated at Eltham College, London and at Warwick University, where he graduated in 1975 with an honours degree in Politics.